Some fairly major genetic switches are scrambled in drosophila raised in artificial zero-G. This is bad news for any form of space travel involving long-term exposure to microgravity, especially those where children are born and raised from scratch. It makes sense, since until a little over a half-century ago, every single one of our ancestors had been in a gravity field of right around 1.0 g for 3.7 billion years; zero gravity is a huge warranty-violation for biochemistry.
Sex has already occurred in space, but that's easy compared to building a whole new human being molecule-by-molecule.
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