As written previously, we can't assume that alien life would be based on the same biochemistry as Earth, and PCR reactions might come up with nothing. A new approach, still relying on nucleic acids, suggests that short oligos interact with many kinds of molecules, and that our sequencing technology could be adapted (and in a way, reversed) to detect even exotic non-nucleic-acid-based life. (Johnson Sarah S., Anslyn Eric V., Graham Heather V., Mahaffy Paul R., and Ellington Andrew D., Astrobiology March 8 2018.)
More on alien evolution here: Finding Extraterrestrial Organics is Old News; Let's Look for Evidence of Life
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